Principles of Inheritance and Variation

Mendelian disorders in humans

  • These are due to mutation in single genes, which are transmitted to offsprings and can be traced in pedigree analysis.
  • Two types are Autosomal and sex linked.
  • Examples of autosomal dominant are : Achondroplasia, Poly / Brachy dactyly, Huntington’s chorea and PTC testing.
  • Examples of autosomal recessive are : Alkaptonuria, Albinism, Tay – such disease, sickle cell anaemia, cystic Fibrosis, Thalassemia
  • Sex linked diseases are Haemophilia colour, blindness, muscular Dystrophy

Part-1: Watch this video for the topic from 0:09 to 13:48

Part-2: Watch this video for the topic from 0:10 to 15:30

Part-3: Watch this video for the topic from 0:09 to 14:39

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